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over 100 Links on this page = 21st Century Bibliography. |
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The AntiAging & Longevity Project was founded in 1998 by a baby boomer Registered Nurse (DOB: 1946) |
rhGH (recombinant human Growth Hormone, Somatropin) is a bio-synthetic FDA approved prescription hormone replacement medication that is rDNA derived & bio-identical w/ 191 amino acid sequence endogenous Anterior Pituitary hGH (Somatotropin)
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Medical studies repeatedly demonstrate that physician directed rhGH therapy and testosterone therapy both have positive effects on many of the diseases associated with aging: cardiovascular disease, mental decline, low energy / fatigue, depression, dementia, body composition (muscle mass vs obesity), bone loss and loss of libido.
MD prescribed rhGH is commonly dispensed by FDA approved medical clinics specializing in hormone replacement. |
The doer alone learnth. ~ Nietzsche (1844-1900)
2007 FDA rhGH Report to Congress: why the FDA approves adult prescription recombinant human Growth Hormone (rhGH).
rHGH is prescribed to treat the symptoms of low endogenous human Growth Hormone production .. not as an AntiAging protocol.
Health and Quality of Life define Personal Wealth. You're never to old to become Healthier ..Wealthier.
"Everyone over 40 years old would be wise to investigate adult HRT because it improves the quality of your life." rhGH Advocate Sylvester Stallone in People Magazine.
Early Retirement .. At what age should one retire to maximize Social Security Benefits?
The worst scenario nay Sayers contend that there could be future unknown medical issues . no objective negative findings to report on a prescription medication that has been prescribed for over 10 years to millions of adult patients to treat Adult GH deficiency .
February 14, 2008: ABC News: rhGH replacement given in the appropriate dosage has minimal negative side effects.
CNN 2007: human Growth Hormone dosages required to produce negative side effects are much higher than prescribed.
rhGH is a prescription hormone replacement medication produced by some of the largest pharmaceutical companies on the planet.
NYSE Pharmaceutical Company literature on Adult rhGH (Somatropin): Eli Lilly (NYSE:LLY) Humatrope®, Pharmacia-Upjohn (NYSE:PNU) Genotropin®, Merck-Serono (NYSE:MRK) Saizen®, Sandoz (NYSE:NVS) Omnitrope®, Genentech (NYSE:DNA) Nutropin®
: Many age associated mental & medical conditions are based in declining endocrine function.
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61 YO Sylvester Stallone discusses using rhGH in preparation for his new Rambo movie.
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Why should adults over 35 consider rhGH injections:
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We could be divided into 3 groups:
All it takes for the wishers & wanters to join the achievers is a sincere desire to optimize their personal situation / life. |
The benefits of adult rhGH Therapy are well documented by 1000s of medical research studies (& daily at baseball stadiums).
The % of 21st century baseball record setting adult athletes utilizing 21st century medicine / rhGH is overwhelmingly convincing as to the effectiveness of rhGH.
If the jocks got their prescription rhGH from a pharmacy with a MD's prescription they violated baseball rules but not law.
rhGH use is currently not detected by any tests because rhGH is identical to natural GH. GH is a naturally produced hormone which is produced in lesser & lesser amounts as part of the aging process.
I loved seeing Barry wallop / knock the cover off a fast ball .. & Roger smoke one past a stunned blinking batter.
Feb 11, 2008 Roger Clemens Congressional Baseball Committee:
April 18, 2008. LA Chronicle: The (prescription) hormone injections have proven to offer amazing health benefits.
Long term medical research HAS BEEN COMPLETED regarding hormone replacement & optimized aging.
AntiAging Medicine as a specialty was founded in the early '90s .. as we baby boomers with 'incredibly high expectations' started hitting the 'middle age wall'.
Again: many of the most problematic symptoms of aging (loss of strength, loss of muscle mass, loss of coordination, cognitive issues) are effectively treated with Hormone Replacement Therapy.
March, 2009: Journal of Clinical Endocrinology & Metabolism: 10 years of rhGH therapy to normalize GH levels in GH deficient adults resulted in normalized muscular strength & neuro-muscular function.
2008 marked 50 Years of Doctor Prescribed injectable hGH Therapy.
In 1958 Tufts University School of Medicine researcher Dr. Maurice Raben treated a 17 year old patient with Growth Hormone extracted from cadaver Anterior Pituitary glands.
Creutzfeldt-Jakob Disease (CJD) is the human form of spongiform encephalopathy, the bovine form of spongiform encephalopathy is commonly known as Mad Cow Disease. Both are transmitted through contaminated Central Nervous System material. From 1958 - 1985 Somatotropin was extracted from cadaver brains & was a source of contaminated CNS material.
1985: Bio-Tech giant Genentech patented 1st generation biosynthetic rhGH Somatrem, methionyl-growth hormone or met-GH. Biosynthetic Somatrem ended the potential of CJD, Crutchfield-Jacobs Disease. Somatrem met-GH is a 192 amino acid molecule.
The Anterior Pituitary secreted hGH molecule, endogenous Somatotropin, has191 amino acids in a specific organic structure. 191 Amino Acid Sequence designates the position each of the 191 amino acids holds in the human GH molecule's amino acid structure. (A change of even 1 amino acid alters the molecule's properties.)
1993-2009: Genentech's second generation biosynthetic rhGH, Somatropin, is rDNA derived & b
Somatropin is 21st century prescription rhGH .. biologically identical with endogenous / natural hGH.
The William J. Rutter Center is situated on the UCSF campus across from Genentech Hall, the campus' other major research building.
Genentech Hall is part of a legal settlement.
UCSF won a court decision that rhGH was developed on the UCSF campus & that Genentech owed UCSF part of Genetech's $2,000,000,000. profit on rhGH.
Genentech Pharmaceuticals patented biosynthetic Insulin in 1982 as well as patenting biosynthetic hGH in 1985.
2008: Genentech Pharmaceutical (NYSE:DNA) remains the leader in HGH research holding the 1993 patent on Somatropin.
The University of California San Francisco Geriatric Resource Center. Information all baby boomers striving to be educated about their personal status should review.
check it out! .. must say it makes us feel good!
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hGH will definitely help baby boomer athletes, ballerinas & pianists achieve a leaner body mass
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July 29, 2003. Human Growth Hormone Gets New FDA Approved Use
The Food and Drug Administration has OK'd the use of growth hormone for children who are healthy but abnormally short and who hope to gain 1 to 3 inches of height.* ( *Our focus is for adult benefit only.) News article link.
Secretagogues require no prescription: Amino Acids that stimulate the endocrine system to increase hormonal secretions.
2005 Syracuse University: Dr. Jim Stoppani, Flex Magazine: A Research Project on men between 18 & 35 has published a report showing that that 6 grams to 9 grams of Arginine acts as a HGH Secretagogue.
A 9 gram L-Arginine serving increased serum HGH by over 60%, from 4mcg/liter to 6.5 mcg/liter.
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Directions on how to make your own custom nutritional stack / Secretagogue stack. You can design / make a 1st thing in the morning stack, pre-workout stack, post-workout stack and pre-sleep stack.. each customized for time of day & situation. By mixing your own stacks you can optimize for your metabolism or goals.
Amino Acid Secretagogue "Releasers" work. The Aminos must be present in grams not milligrams(>20 pills) + protocol adherence |
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Over 150 Supplements.. AAKG, Glutamine, Secretagogues, Weight Loss, Whey, L-Ornithine .. most with free shipping. Supplements supplement a complete diet .. not replace a complete diet.
Directions on how to make your own custom nutritional stack. Save $s & be assured of ingredients
Prepackaged Secretagogue products are convenient .. purchase individual amino acids & nutrients to make your own stack.
Dr. Ronald Klatz' 1998 book Grow Young With HGH is the Amino Acid Secretagogue Bible.
"HGH" Sprays are stupid! Spray "not-HGH" in nanograms(ng)=.000000001 gram(billionth!)="drops in an Olympic pool". No way, José!
It's not the men in my life, it's the life in my men. ~ Mae West... & .. the life in my woman! ED |
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A man 40 years old has less than 1/2 the testosterone a man of 25 has.
Low levels of testosterone increase death rate for men over 50. University of California, San Diego School of Medicine.
Testosterone replacement therapy may help elderly men with mild Alzheimer's disease. The University of California, Los Angeles team found that replacement hormone therapy significantly improved quality of life for Alzheimer's patients.
HGH and Testosterone can provide an improved quality of life. FACT!
Dr. William Regelson, University of Virginia School of Medicine reports that the hormone DHEA is "one of the best biochemical bio-markers for chronological age.
0ver 50% of Testosterone is produced from DHEA.
Considering Testosterone Therapy?
Alzheimer's: The Baby Boomer Nightmare.
Exercise at least twice a week in sessions lasting 20 minutes to reduce your
risk of developing
Alzheimer's Disease by 60%.
Begin exercise by your late 40s or early
50 to reduce the risk of dementia by about 50%
..
even a few brisk walks per week can have a measurable effect
Tobacco
kills the equivalent of 30 x 747 hijackings per day
Cigarettes kill more than 3 9/11s
DHEA &
Testosterone Store






Do not listen to anyone who says it's okay to gain 10 pounds per decade after your 40s. BUNK!
.... Hard on your spirit .. hard on your confidence .. hard on your wardrobe |
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A low calorie diet is on your route to graceful aging
Without lifestyle changes 25% of all people born today will develop Type 2 Diabetes.
High protein diets result in the release of a hormone, PYY, that curbs hunger in both obese and normal weight people. PYY levels are lowest amongst obese people. Dr. Batterham reported the dietary changes required in average person's diet would be small - 2-3%, no where near the protein levels advocated by the Adkins diet, small increases in protein intake and small reductions in carbohydrate intake are effective.
Exercise and weight control can reduce Type II Diabetes by 60%
You have to stay in shape. My grandmother, she started walking five miles a day when she was 60. She's 97 today and we don't know where the hell she is. ~Ellen DeGeneres
The risk of heart disease could be cut by up to 55% if people became physically active by 40.
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There are positive hormonal responses with both aerobic and anaerobic exercise
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Hormonal demise is often responsible for the physical & cognitive issues experienced with aging.
Natural Anterior Pituitary hGH is Somatotropin. Somatropin is rhGH. Both are 191 amino acid chain hormones.
'95-'08, 21st Century 2008: rhGH Somatropin is dispensed under assorted Trade Names. 3rd Generation rhGH, long lasting, is in Second Phase FDA Testing. |
Several rhGH Somatropin brands come pre-mixed in an easy to administer auto-injection device.
Omnitrope Pen® Injection Device video: Step by step video instructions for the Omnitrope Pen (Sandoz Somatropin)
Saizen Cool Click® Injection Device. (Merck-Serono Somatropin) |
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Benefits of Adult rhGH Therapy.
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April 18, 2008. LA Chronicle: The hormone injections have proven to offer amazing benefits Dr Ronald Klatz of the American Academy of AntiAging Medicine, “Nearly 20,000 clinical studies conducted around the world document the broad benefits of pharmacological hGH therapy. " February, 2008: Dr. Andre Berger reports that in his LA Clinic, "... human Growth Hormone therapy (rhGH) for the treatment of adult growth hormone deficiencies has helped thousands of my patients, men and women, feel more energetic and more vibrant." & This second Mayo Clinic report provides a list of aging symptoms with the whys. |
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AntiAging Medicine is often referred to as Aging Management Medicine. A realistic goal of an AntiAging program is to delay the onset of & to slow the progression of Aging's Symptoms A Patient's Advocate Medical Provider / Doctor is necessary for optimized aging. The better the Doctor the better the examination room communication. 2 way communication. A good Doctor listens. Doctor shopping to achieve your personal goals is 100% acceptable.
HMO Doctors are often not dedicated to individualized medicine orpersonalized patient care. Demand personalized medical care!!! Choice of medical care provider should not be a random pick & certainly not a decision delegated to a HMO. |
Women's International Pharmacy can provide a list of competent doctors by state.
A medical check up is advised before beginning any nutritional, dietary or exercise program.
Realistic assessment of your current physical condition, to include genetics as well as wear & tear.
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Mayo Clinic Human Growth Hormone report demonstrates hGH's benefits: Bolster the heart's ability to contract Improve mood and motivation Increase exercise capacity Increase muscle mass Increase bone density Decrease body fat |
Primary factors for an early demise:
most are personally or medically controllable. Most stupid choices are fairly obvious mistakes. Doh! |
"If I'd know I was going to live this long I'd taken better care of my self" ~ Mickey Mantle (1931-1995)
- Clean living, diet, exercise & weight control, is the best way to beat disease.
- stop smokin', drink intelligently, exercise .. & use protection when you should
- we have only 1 dietary rule: Eat nothing today that you will regret eating tomorrow.
June, 2008. Us News & World Report: Restful sleep is associated with healthy / successful aging.2004, Journal of the American Medical Association: University of Chicago Researchers found that the first stage of age-related deterioration of sleep quality in men occurs between the ages of 25 and 45. They're sleeping as long as younger men, but they're spending less time in restorative deep sleep.
There is strong relationship between sleep quality and physical and mental health.
Proper rest is critical. True rest occurs in REM / Delta (DEEP) Sleep. When was the last time you had a vivid dream?
University of Chicago researchers found that the first stage of age-related deterioration of sleep quality in men occurs between the ages of 25 and 45.
University of Chicago researchers found that the first stage of age-related deterioration of sleep quality in men occurs between the ages of 25 and 45.
When was the last time YOU had a vivid dream? Dreaming, REM Sleep, is a good thing!
Melatonin, a hormone secreted by the Pineal Gland, is extremely helpful in resolving age related sleep issues.
Fall 2007: MIT study confirms Melatonin's value as sleep aid
I'll let you be in my dream, if I can be in yours ~ Bob Dylan, circa 1963
New England Journal of Medicine. THE 1990 report that started the hGH revolution: "Diminished secretion of growth hormone is responsible in part for the decrease of lean body mass, the expansion of adipose-tissue mass, and the thinning of the skin that occurs in old age.
Dr. Rudman "(N Engl J Med 1990; 323:1-6.)March 27, 2008: Researchers at UC Berkeley, Shanghai Institute & Columbia University have identified hGH & it's metabolites IGF-1 & IGF-2 as axon guidance molecules .. hGH, IGF-1 & IGF-2 actually facilitate the connectivity within the brain of individual neuron cells. Each brain neuron connects to 10,000 other neurons via the axons. hGH, IGF-1 & IGF-2 greatly facilitate this neuron > axon process.
Science Daily, December 22, 2006: A medical report from the University of Pittsburg Medical School, & supported by the National Institute of Aging, takes HRT's benefits to the cellular / DNA level.
Report 1: The accumulation of genetic damage in our cells is a major contributor to how we age.
Report 2: There is a direct relationship between DNA damage & aging. Aging is driven by a build up of damaged DNA in cells. These findings unify 2 of the theories on aging.
Laura Niedernhofer, M.D., Ph.D., Professor of Molecular Genetics, U of Pittsburgh Medical School, reports, "..how we respond to cellular DNA damage is determined by the HGH & Insulin pathways."
The rate of physical & mental decline we experience with aging is determined by cellular / DNA damage. Cellular / DNA damage we all accumulate over our lifetimes, but our response to that damage / repair of that damage is unique & individual.
The higher the somatotroph (growth hormone) axis level the better.
This medical school study on DNA damage demonstrates positive repair is directly proportional to somatotroph (growth hormone secretion regulator hormone GHRH) level.
Mayo Clinic, "These results document that growth hormone can help healthy older adults who have low levels of growth hormone regain some of their youth and vitality."
Colorado State University: "..frailty, muscle atrophy, relative obesity, increased frequency of fractures and disordered sleep. These clinical signs of aging are, without doubt, the manifestation of a very complex set of changes which involve, at least in part, the GH-axis (= growth hormone level)."
2007, Journal of Endocrinology. Growth hormone is critical to maintaining bone mass.
".. GH is able to modulate bone remodeling by directly influencing osteoblast-osteoclast cross-talk."
Edward M. Lichten, M.D.,P.C. "One of HGH’s most dramatic effects is on the connective tissue, muscle, and healing potential of the skeletal system."
The positive effect HGH has on bone mass is documented by bone scan
Many age related medical conditions are positively affected by Hormone Replacement Therapy, HRT.
CNN: Hormone Replacement, HRT, wards off Dementia & Cardiac disease.
Journal of Endocrinology Nov, 2007: HGH is a beneficial treatment for cardiac disease via increased bioavailability of Nitric Oxide
University of Chicago researchers found that the first stage of age-related deterioration of sleep quality in men occurs between the ages of 25 and 45.
High cholesterol is linked to tied to brain impairment, memory loss, heart attacks and stroke.
The first step is the hardest step! Many of the health issues, age related medical conditions, middle-aged persons begin to experience are directly related to diminished hormone production. rhGH Business News
March, 2009: Long term rhGH patent holder Altus (NYSE: ALTU) prepares to lay off 75% of staff. Reports long term rhGH, ALTU-238, is on path for US FDA approval.
Akela Pharma, Canadian Bio Tech startup, has dedicated considerable resources into research into GHRH. Alkela Pharma has settled the research technology lawsuit.
January 24, 2008 The U.S. Food and Drug Administration has approved Cangene Corp's Accretropin Brand Somatropin recombinant human growth hormone injection for pharmaceutical dispensing.
January, 2008. Biopharmaceutical company Tercica, Inc. (TRCA) has begun Phase II clinical testing the combination of Genentech, Inc.'s (DNA) recombinant human growth hormone Nutropin AQ and Tercica's recombinant insulin-like growth factor-1 Increlex. Expected to be on the market in 2009.
January, 2008. Auxilium Pharmaceuticals (NASDAQ: AUXL) in conjunction with Bentley Pharmaceuticals (NYSE: BNT) has patented a new 1% testosterone gel Testim®..It is expected to market in 3rd quarter 2008.U.S. Patent No. 7,320,968 expires January 2025 December, 2007.
Israeli Biotech firm TEVA has purchased CoGenesys for $400m US. CoGenesys reciently aquired a patent on a new production technique Albumin Fusion technology an advancement in recombinant DNA technology.
TEVA produces rhGH under the Trade Name Tev-Tropin.
July, 2007: US based US-based Dowpharma (Dow Chemical Pharmaceuticals) has licensed an Indian Pharmaceutical firm to produce rhGH using Pfenex Expression Technology. Pfenex Expression Technology thus far has produced higher yields & lower cost than current (Somatrem's Inclusion Body Technology & Somatropin's Protein Secretion Technology). Dowpharma expects to be a major player in the global market with a production goal of 5% of the global rhGH from the 1 India plant market by 2011.
April, 2006: The US FDA was ordered by a Federal judge to stop with holding approval for Sandoz's Omnitrope Somatropin. The FDA granted approval on June1, over the objection of Pfizer's lobbyist greedily seeking protection from fair competition. Omnitrope is bio-identical to Pfizer's Somatropin rhGH but is set to be priced 25% lower! Sandoz was forced to wait over 3 years to market it's bio-identical rhGH because of the Pfizer lobbyist's 'scam' to avoid fair competition.
December 20, 2006: Genentech, the worlds second largest biopharmaceutical / biotechnology company, acquires a once per week rhGH technology from Altus!
August, 2006 - A University of Pennsylvania School of Medicine research program involving the relationship between non-coding RNAs and the hGH gene is leading to an understanding how remote RNA effects the function or dysfunction of the hGH gene. May, 2006: After 6 months on Pfizer's new oral medication to increase Human Growth Hormone, HGH, middle aged patients demonstrated significant improvement in a multitude of tasks.
Pfizer has entered a rhGH capacity expansion phase investing us$500 million in a expanded facility, to meet requirements of global manufacturing of Genotropin (somatropin), a top-selling human growth hormone This report from Business Wire indicates rhGH is under study to be included in Medicare part D reimbursement. Calls for Biogeneric Insulin and Human Growth Hormone are part of the 2007 Medicare Part D review. See: Content outline section.
LillyMedicareAnswers, an "Outside Part D" Medicare Part D Patient Assistance Program by the Health and Human Services Office of Inspector General (OIG). OIG approval of LillyMedicareAnswers paves the way for the full implementation of Humatrope, rhGH, to low-income seniors who are experiencing gaps in coverage.
Wisconsin Medicaid has re-reviewed several brands of rhGH and will add them to the PDL effective for DOS on and after April 3, 2006. Norditropin, Nutropin AQ, Saizen, Tev-Tropin. Of that group Saizen would be our choice.
Current consensus is to withhold growth hormone from patients with cancer.
Persons under the care of a Physician, on complex medical plans or taking multiple medications should always consult with their Physician before any dietary or nutritional supplementation changes are made. Current cancer patients, cancer patients in remission and previous cancer patients should consult with their Physician before considering any new exercise or nutrition program
Old, worn ... & outstanding .. Experience Matters!
Willie, at 75, laments, "There aren't as many mirrors in my house any more."
The VA is in dire need of R.N. Medical Case Managers .. for injured military: 1-800-949-0000
For many degenerative diseases 21st century stem cell medicine offers huge potential.
2006: Stems cells help with age related macular degeneration (30% of people over 75) in test animals. Dr. Neal Adams of the Wilmer Eye Institute in Baltimore, “success with embryonic stem cells in test animals shows us some of the hope that regenerative medicine possesses."
Stem cells offer potential to repair cartilage damaged by OsteoArthritis. The pain from osteoarthritis or degenerative arthritis can be totally life altering. Stem cells successfully treating osteoArthritus in dogs.
Stem cells facilitate broken bone repair.
Stem cells aid brain injury repair. How long before success with Alzheimer's?
2007: Under a program named Stem Cell Life. <66> 02 613-1515 (news report Thai Stem Cell Life) parents in Thailand are saving stem cells from their child's umbilical cord to provide a cure to any major medical condition / injury that could develop later in their child's life.
In the 21st century microbiology & advanced research are producing medications that can be used to "level the playing field" in many areas of endeavor.
College students take the attention-deficit drugs Adderall and Ritalin to help them focus for exams, said Dr. Joji Suzuki of Boston University Medical Center. ADD med use is so common there was a "Law & Order" episode based on college ADD meds w/ a plot line involving previously poor students making the deans list.
Musicians take the blood pressure-lowering drug Inderal to calm their nerves before a tryout or performance", composer Stuart Dunkel.
The PPARδ (Delta) Cellular Receptor is involved at the cellular level with metabolism & cellular utilization of insulin, Phase I FDA testing on this new medication to increase the effectiveness of the PPAR receptorincreases muscularity & endurance in test animals.This is not a hormone but a medication to improve the effectiveness of the hormone's cellular receptor
Report filed with the FDA (click for .pdf file) demonstrate a 200% improvement in test animal endurance + the improvement in body composition.
Will this major advance in the treatment of Type II Diabetes, 54 million Americans have Type II Diabetes, become a restricted protocol because of increased muscularity & endurance?
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